SHIGELLOSIS

SHIGELLOSIS

SHIGELLOSIS

Shigella dysentery- common, self-limited, mild but sometimes serious.

S sonnei, S flexneri.

S dysenteriae causes most serious form of disease.

Shigellae invasive organisms, infective dose is low at 102–103 organisms.

Symptoms and Signs:

Shigella dysentery- common, self-limited, mild but sometimes serious.

Diarrheal stool largly mixed with blood & mucus.

Fever, chills, headache, anorexia and malaise.

Tender abdomen may present.

Sigmoidoscopy- inflamed, engorged mucosa with punctate & large area ulceration sometimes.

Investigation:

Stool shows- leukocytes & red cells.

Stool culture positive for shigellae (~5%)

Amebic dysentery- finding amoebas in fresh stool specimen.

Ulcerative colitis is also cause of bloody diarrhea.

Complications:

Temporary disaccharidase deficiency after diarrhoea.

Reactive arthritis in HLA-B27 person infected by Shigella.

Hemolytic-uremic syndrome rarely seen.

Treatment:

Treatment of dehydration & hypotension- intravenous fluids.

Tab. ciprofloxacin, 750 mg orally twice daily for 7–10 days, or

Tab. levofloxacin, 500 mg orally once daily for 3 days or

Ceftriaxone, 1 g intravenously once daily for 5 days.

Supportive & symptomatic treatment.

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